Summary information and primary citation
- PDB-id
-
6ytf;
DSSR-derived features in text and
JSON formats
- Class
- ribosome
- Method
- cryo-EM (3.0 Å)
- Summary
- Acinetobacter baumannii ribosome-tigecycline complex -
30s subunit head
- Reference
-
Nicholson D, Edwards TA, O'Neill AJ, Ranson NA (2020):
"Structure
of the 70S Ribosome from the Human Pathogen Acinetobacter
baumannii in Complex with Clinically Relevant
Antibiotics." Structure,
28, 1087-1100.e3. doi: 10.1016/j.str.2020.08.004.
- Abstract
- Acinetobacter baumannii is a Gram-negative bacterium
primarily associated with hospital-acquired, often
multidrug-resistant (MDR) infections. The
ribosome-targeting antibiotics amikacin and tigecycline are
among the limited arsenal of drugs available for treatment
of such infections. We present high-resolution structures
of the 70S ribosome from A. baumannii in complex with these
antibiotics, as determined by cryoelectron microscopy.
Comparison with the ribosomes of other bacteria reveals
several unique structural features at functionally
important sites, including around the exit of the
polypeptide tunnel and the periphery of the subunit
interface. The structures also reveal the mode and site of
interaction of these drugs with the ribosome. This work
paves the way for the design of new inhibitors of
translation to address infections caused by MDR A.
baumannii.
